First of all, I'm a huge saver, so Rose wasn't ever that annoying to me because I wouldn't save just when I was turning off the game, or when I was anticipating a big boss fight or dramatic scene. Secondly, considering the meta themes of the game, I felt that the player was supposed to feel somewhat hostile to Rose. After all, she represents Raiden's fictional (but real to him) life, and Raiden's independence from the player. This is naturally against our own interests.
Finally, even though I liked Raiden, MAN did I also think of him as a nasal-voiced, pissy little punk. So Rose bugging Raiden wasn't irritating, it was justice.
Re: 123
Finally, even though I liked Raiden, MAN did I also think of him as a nasal-voiced, pissy little punk. So Rose bugging Raiden wasn't irritating, it was justice.