No, Remus/Tonks was by far the most popular Lupin het ship. People noticed the hints in OotP, which I scoffed about at the time. Possibly because I too viewed them both as coded gay, or Lupin at the very least. And because people always saw "hints" between any two members of the opposite sex as possible future romances in HP.

Charlie/Tonks was pretty popular, too, but not as popular as Lupin/Tonks.