As someone who recently went on meds for crippling anxiety..... yeah, kinda yeah. I mean, his idiosyncrasies make him really fun to watch and a Sheldon-on-meds would probably be really boring in the show (unless it's valium Howard slipped him again), but sometimes you can tell that as funny as his obsession with having four people at the Chinese restaurant is, on the inside stuff like that is really distressing to him.