Stuart in The Big Bang Theory. The fact that he's a loser is a running joke and none of his so-called friends seem to care that he's actually depressed. It's a shame because he started out okay and even charmed Penny enough for them to go out, but I guess his self-esteem took a nosedive after she dumped him. I feel really sorry for him and don't like how he's the butt of so many jokes.