This is all only my opinion.
Murderbot seems to act and express a lot more emotion than in the book, very early on.
Dr. Mensah and everyone else are portrayed in a really hippy-dippy, almost silly way, way too naive and goofy.
Random sexualizing of Murderbot by a character that went on way too long.
Those are the things that really stand out in the few eps/bits I watched.

The *inclusion* of scenes from Sanctuary Moon is awesome.